Acute kidney injury among intensive care unit patients in Denmark: temporal changes in mortality and kidney outcomes from 2010 to 2024
Authors' conclusion
In this cohort of ICU patients with AKI, mortality and risk of CKD decreased over time, while the risk of KF remained stable.
Study context
- Population
- Adults with a first-time intensive care unit (ICU) admission and acute kidney injury (AKI) (creatinine changes within 7 days of ICU admission), Denmark, 2010–2024patients with AKI
- Participants
- 48,529 adults
- Exposure
- Three calendar periods: 2010-2014 vs 2015-2019 vs 2020-2024
- Outcome
- Risks of chronic kidney disease (CKD), kidney failure (KF) and death
- Follow-up
- One year after ICU admission
Methodological detailscompeting risk analysis
- Competing risk analysis
Main finding
As reported in the abstract
Mortality, days 7–89 · seven to 89 days
Observational data: associations, not effects.
Further findings
| Outcome | 2010-2014 | 2015-2019 | 2020-2024 |
|---|---|---|---|
| Mortality, days 90–365 | 10.3% (95% CI 9.5%–11.0%) | 10.2% (95% CI 9.7%–10.7%) | 9.5% (95% CI 9.1%–10.0%) |
| Risk of CKD (outpatient eGFR <60 ml/min/1.73 m² for >90 days), death as competing risk · 90 to 365 days | 21.0% (95% CI 19.9%–22.1%) | 19.8% (95% CI 19.1%–20.6%) | 17.3% (95% CI 16.7%–17.9%) |
| Risk of kidney failure (eGFR <15 ml/min/1.73 m², hospital diagnosis, kidney transplantation or chronic kidney replacement therapy), death as competing risk · 90 to 365 days | 2.2% (95% CI 1.9%–2.6%) | 2.1% (95% CI 1.9%–2.3%) | 2.0% (95% CI 1.8%–2.3%) |
Original publication
Acute kidney injury among intensive care unit patients in Denmark: temporal changes in mortality and kidney outcomes from 2010 to 2024. Crit Care. Published 10 June 2026. doi:10.
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