Trends in renal replacement therapy use in intensive care unit: insights from a French multicenter cohort
Authors' conclusion
Among critically ill patients with AKI, RRT use decreased in the past decade.
Study context
- Population
- Intensive care unit (ICU) patients with acute kidney injury (AKI) requiring invasive mechanical ventilation and/or catecholamine infusion, CUB-Réa database, 2008–2019
- Participants
- 45,242 eligible ICU stays
- Exposure
- Renal replacement therapy (RRT) use across periods 2016-2019 and 2012-2015 vs 2008-2011
- Outcome
- Temporal trend in RRT utilization
Methodological detailsmulticentre, interrupted time series, multivariable logistic regression
- Multicentre
- Interrupted time series
- Multivariable logistic regression
Main finding
As reported in the abstract
RRT use
Each group vs 2008-2011Odds ratio (95% CI)
2012-2015
0.91(0.87–0.96)
2016-2019
0.80(0.76–0.84)
- Trend across periods
- P < 0.0001
- Overall RRT use
- 16,999 (37.6%)
Observational data: associations, not effects.
Secondary outcomes
Monthly trend after July 2016 breakpoint (AKIKI publication), adjusted interrupted time series (ITS)
| RR per year (95% CI) | ||
|---|---|---|
| Post-intervention | 0.97 (0.94–0.99) | |
| 0.512Relative risk per year (log scale) |
- Monthly trend after July 2016 breakpoint (AKIKI publication), adjusted ITS: only post-intervention monthly trend statistically significant
Annual crude RRT rate per 1000 ICU stays
- Baseline
- 441
- 2019
- 339
- Relative reduction
- 20.8%
RRT modality
- Intermittent RRT declined, continuous modestly increased
Original publication
Trends in renal replacement therapy use in intensive care unit: insights from a French multicenter cohort. Intensive Care Med. Published 25 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →