Long-term outcomes after severe acute kidney injury in critically ill patients: the SALTO study
Authors' conclusion
Severe AKI in critically ill patients was associated with a high proportion of death within the first 2 months but less so during long-term follow-up. A quarter of long-term survivors experienced a WRF and suffered from a noticeable impairment of quality of life. Renal replacement therapy initiation strategy was not associated with mortality outcome.
Study context
- Population
- Critically ill patients with severe acute kidney injury (AKI) included in the AKIKI trial of renal replacement therapy (RRT) initiation strategy, surviving after 60 dayssurvived after 60 days
- Participants
- 316 patients
- Primary endpoint
- Long-term survival, renal outcome and health related quality of life (HRQOL)
Methodological detailsmulticentre, long-term follow-up
- Multicentre
- Long-term follow-up
Primary result
As reported in the abstract
- Overall survival rate at 3 years from inclusion
- 39.4% (95% CI 35.4 to 43.4)
- Worsening of renal function at follow-up, of 175 with available data
- 46
- Overall incidence of worsening of renal function (WRF)
- 26%
- Cumulative incidence of WRF at 4 years
- 20.6% (95% CI 13.0 to 28.3)
- Chronic dialysis required
- 15
- Chronic dialysis, % of patients who survived after day 90
- 5%
- Median EQ-5D index value (IQR 0.40 to 1.00), noticeable alteration of quality of life
- 0.67
Further findings
EQ-5D questionnaire response among long-term survivors
- Answered EQ-5D, of 226 long-term survivors
- 80
- Response rate
- 35%
Influence of RRT initiation strategy on long-term outcomes
- Initiation strategy for RRT had no effect on any long-term outcome
Original publication
Long-term outcomes after severe acute kidney injury in critically ill patients: the SALTO study. Ann Intensive Care. Published 13 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →