Time to Renal Replacement Therapy Initiation in Critically Ill Patients With Acute Kidney Injury: A Secondary Analysis of the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial
Primary result · All-cause mortalityResult — go to the resultAdjusted odds ratio 0.63 95% CI 0.42–0.94Authors' conclusion
Among patients with no urgent indications and who received RRT in the standard strategy of the STARRT-AKI trial, longer deferral of RRT initiation was not associated with a higher risk of mortality.
Study context
- Population
- Critically ill patients with severe acute kidney injury (AKI) without urgent indications for renal replacement therapy (RRT), allocated to the standard strategy of the STARRT-AKI trial903 (62%) received RRT
- Participants
- 1,462 patients
- Comparison
- Progressively longer time from randomisation to RRT initiation
- Primary endpoint
- All-cause mortality
- Follow-up
- 90 days
Methodological detailspost hoc, multinational
- Post hoc
- Multinational
Primary result
As reported in the abstract
Adjusted odds ratio
0.63
95% CI 0.42–0.94
Quartile 4 vs Quartile 1
aOR 0.63 (95% CI 0.42–0.94)
Secondary outcomes
RRT-free days, hospital-free days, ICU and hospital LOS
- No association with time to RRT initiation
RRT dependence · 90 days
- Longer delay to RRT initiation had a linear association with RRT dependence
Original publication
Time to Renal Replacement Therapy Initiation in Critically Ill Patients With Acute Kidney Injury: A Secondary Analysis of the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial. Crit Care Med. Published 3 March 2025. doi:10.
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