Trajectories of fluid management after the initiation of renal replacement therapy in critically ill patients: a secondary analysis of the STARRT-AKI trial
Primary result · 90-day mortalityResult — go to the resultAdjusted odds ratio 0.48 CI 0.32–0.70Authors' conclusion
Distinct CFB/NUF trajectories convey prognostic information beyond single-day fluid balance or NUF values
Study context
- Population
- Critically ill patients in the standard-strategy arm of STARRT-AKI who initiated renal replacement therapy (RRT)included in primary analysis
- Participants
- 855 patients
- Comparison
- Cumulative fluid balance (CFB)/net ultrafiltration (NUF) trajectory class B vs class A
Methodological detailslatent trajectory analysis, multivariable joint longitudinal models
- Latent trajectory analysis
- Multivariable joint longitudinal models
Primary result
90-day mortality · 90 days
Adjusted odds ratio
0.48
CI 0.32–0.70
P < 0.001
By group
Class B vs Class A
aOR 0.48 (CI 0.32–0.70); P < 0.001
As reported in the abstract
Further findings
Higher CFB and mortality, time-dependent (Class A)
| aHR (95% CI) | P value | ||
|---|---|---|---|
| Higher CFBOnly in class A trajectory | 1.29 (1.03–1.55) | P = 0.03 | |
| 0.512Adjusted hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Trajectories of fluid management after the initiation of renal replacement therapy in critically ill patients: a secondary analysis of the STARRT-AKI trial. Crit Care. Published 27 May 2025. doi:10.
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