The interaction of net ultrafiltration rate with urine output and fluid balance after continuous renal replacement therapy initiation: A multi-Centre study.
Main finding · UO per 1 mL/kg/h increase in NUFResult — go to the resultAdjusted change in UO −1.5 mL/kg 95% CI −3.1 to 0.04Authors' conclusion
A higher NUF rate was not significantly associated with a greater immediate and sustained reduction in UO after CRRT commencement. FB before CRRT was also not associated with a greater reduction in UO.
Study context
- Population
- Continuous renal replacement therapy (CRRT)-treated patients admitted to two tertiary ICUs
- Participants
- 1,030 patients · 2 tertiary ICUs
- Exposure
- Higher vs lower net ultrafiltration rate during CRRT
- Outcome
- Association of NUF with UO, and modulation by pre-CRRT FB, after CRRT start
- Follow-up
- 24 h after CRRT started
Methodological detailsmulticentre, multivariable analysis
- Multicentre
- Multivariable analysis
Main finding
UO per 1 mL/kg/h increase in NUF
Adjusted change in urine output (UO)
−1.5 mL/kg
95% CI −3.1 to 0.04
P = 0.064
Higher NUF (per 1 mL/kg/h increase)
adjusted change in UO −1.5 mL/kg (95% CI −3.1 to 0.04); P = 0.064
Per 1 mL/kg/h increase, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mean hourly UO before vs after CRRT start · 24 h after CRRT started
- Mean hourly UO decreased from 25.5 mL to 11.9 mL
- P < 0.001
Baseline characteristics
- Median age (IQR 48-70)
- 60 years
- Median APACHE III (IQR 76-114)
- 94
- Median NUF rate
- 0.7 mL/kg/h
Original publication
The interaction of net ultrafiltration rate with urine output and fluid balance after continuous renal replacement therapy initiation: A multi-Centre study. J Crit Care. Published 20 May 2024. doi:10.
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