Fluid balance neutralization secured by hemodynamic monitoring versus protocolized standard of care in patients with acute circulatory failure requiring continuous renal replacement therapy: results of the GO NEUTRAL randomized controlled trial
Authors' conclusion
In patients with vasopressors, a UFNET fluid removal strategy secured by a hemodynamic protocol allowed active fluid balance control, compared to the standard of care.
Study context
- Population
- Adults receiving vasopressors, continuous renal replacement therapy (CRRT) since ≤ 24 h and cardiac output monitoringmITT: 21 interventions, 24 controls
- Participants
- 55 adults
- Comparison
- Intervention vs Control
- Interventionn = 25
- Controln = 30reference
- Primary endpoint
- Cumulative fluid balance
- Follow-up
- 72 h
Methodological detailsopen-label, parallel-group, multicentre, proof-of-concept, June 2021 to April 2023
- Open-label
- Parallel-group
- Multicentre
- Proof-of-concept
- June 2021 to April 2023
Primary result
As reported in the abstract
Difference
4942 ml
95% CI 2736–6902
P < 0.01
By group
Intervention
−2650
median · IQR −4574–-309 · ml
Control
1841
median · IQR 821–5327 · ml
Intervention vs Control
difference 4942 ml (95% CI 2736–6902); P < 0.01
Secondary outcomes
Hemodynamics, oxygenation and day-90 mortality
- Did not statistically differ between arms
- ITT population
Safety
Number of HIRRT (hemodynamic instability associated with CRRT) · 72 h
- Did not statistically differ between arms
Original publication
Fluid balance neutralization secured by hemodynamic monitoring versus protocolized standard of care in patients with acute circulatory failure requiring continuous renal replacement therapy: results of the GO NEUTRAL randomized controlled trial. Intensive Care Med. Published 17 October 2024. doi:10.
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