Renal replacement therapy initiation strategies in comatose patients with severe acute kidney injury: a secondary analysis of a multicenter randomized controlled trial
Primary result · Transition intensity from coma to awakeningResult — go to the resultHazard ratio 0.36 CI 0.17–0.78Authors' conclusion
In comatose patients with severe AKI, a more-delayed RRT initiation strategy resulted in a lower chance of transitioning from coma to awakening.
Study context
- Population
- Comatose patients (RASS < - 3, irrespective of sedation) with severe acute kidney injury (AKI) (oliguria >72 h and/or blood urea nitrogen >112 mg/dL)
- Participants
- 168 comatose patients
- Comparison
- More-delayed vs delayed renal replacement therapy (RRT) initiation strategy
- Delayedn = 90reference
- More-delayedn = 78
- Primary endpoint
- Transition from coma to awakening
- Follow-up
- 28 days after randomization
Methodological detailspost hoc analysis, multi-state model
- Post hoc analysis
- Multi-state model
Primary result
Transition intensity from coma to awakening
Hazard ratio
0.36
CI 0.17–0.78
P = 0.010
More-delayed vs Delayed
HR 0.36 (CI 0.17–0.78); P = 0.010
As reported in the abstract
Further findings
Time spent awake
Sensitivity analyses (sedation status; sedation practices across centers)
- Comparable results
Original publication
Renal replacement therapy initiation strategies in comatose patients with severe acute kidney injury: a secondary analysis of a multicenter randomized controlled trial. Intensive Care Med. Published 26 February 2024. doi:10.
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