The association of early glomerular filtration kinetics and urinary urea excretion with subsequent renal replacement therapy under a delayed strategy in severe acute kidney injury
Authors' conclusion
Early glomerular filtration kinetics and urinary urea excretion were associated with subsequent RRT initiation under a delayed strategy.
Study context
- Population
- ICU adults with KDIGO stage-3 acute kidney injury (AKI) managed with a protocolized delayed renal replacement therapy (RRT) strategy31 (28%) required RRT
- Participants
- 110 adults
- Exposure
- Kinetic GFR (kGFR) D0-D1 vs UUEI D1 vs Combined model
- Outcome
- Discrimination (AUC) for subsequent RRT initiation
Methodological detailsbicentric, bootstrap internal validation
- Bicentric
- Bootstrap internal validation
Main finding
As reported in the abstract
Subsequent RRT initiation
| Group | AUC | Optimism-corrected AUC |
|---|---|---|
| kGFR D0-D1 | 0.81 [0.72-0.89] | — not stated in the abstract |
| UUEI D1 | 0.74 [0.63-0.82] | — not stated in the abstract |
| Combined model | 0.85 ([0.76-0.91]) | 0.83 |
AUC
kGFR D0-D10.81 [0.72-0.89]
UUEI D10.74 [0.63-0.82]
Combined model0.85 ([0.76-0.91])
Optimism-corrected AUC
kGFR D0-D1— not stated in the abstract
UUEI D1— not stated in the abstract
Combined model0.83
— not stated in the abstract
Observational data: associations, not effects.
Further findings
Discrimination adjusted for SOFA and oliguria (sensitivity analysis)
- Discrimination remained stable after adjustment for SOFA and oliguria
Original publication
The association of early glomerular filtration kinetics and urinary urea excretion with subsequent renal replacement therapy under a delayed strategy in severe acute kidney injury. Crit Care. Published 5 May 2026. doi:10.
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