Predictive factors of successful renal replacement therapy weaning : Deciding On patients Orientations after Renal replacement therapy Stopping (The DOORS study)
Authors' conclusion
The UNDERSCORE, derived from a homogeneous conservative RRT initiation cohort and validated in a diverse ICU population, provides a bedside tool to estimate the probability of sustained RRT discontinuation after an initial clinician-initiated stop.
Study context
- Population
- ICU patients with KDIGO stage 3 acute kidney injury (AKI) managed with a conservative renal replacement therapy (RRT) initiation approach who underwent an RRT weaning attempt (discontinuation for ≥ 3 consecutive days)554 received RRT in AKIKI/AKIKI2
- Primary endpoint
- Successful weaning (no RRT resumption)
- Follow-up
- 7 days
Methodological detailspost-hoc analysis, multicentre, prediction model development, external validation
- Post-hoc analysis
- Multicentre
- Prediction model development
- External validation
Primary result
As reported in the abstract
Successful RRT weaning and UNDERSCORE discrimination
| Group | Value | AUC |
|---|---|---|
| Derivation | 56% | 0.86 |
| External Swiss | 81% | 0.73 |
Value
Derivation56%
External Swiss81%
AUC
Derivation0.86
External Swiss0.73
- Derivation AUC 95% CI
- 0.80-0.91
- External validation AUC 95% CI
- 0.66-0.80
- Six predictors retained: RRT duration before attempt, septic shock on admission, baseline serum creatinine, and after the attempt vasopressor use, invasive mechanical ventilation, urine output
- 6
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Predictive factors of successful renal replacement therapy weaning : Deciding On patients Orientations after Renal replacement therapy Stopping (The DOORS study). Intensive Care Med. Published 17 March 2026. doi:10.
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