Effects of the urinary urea excretion index on the decision to wean intensive care unit (ICU) patients with acute kidney injury from renal replacement therapy: a before-after multicentre study (D-STOP)
Main finding · Catheter-free daysResult — go to the resultAdjusted rate ratio 1.11 95% CI 1.03–1.19Authors' conclusion
These results confirm that a UUEI-based protocol is a safe technique to prompt withdrawal of the RRT catheter in patients with AKI requiring RRT during their ICU stay.
Study context
- Population
- ICU patients with non-obstructive acute kidney injury (AKI) requiring renal replacement therapy (RRT)
- Participants
- 179 vs 130
- Comparison
- Before vs After
- Beforen = 179reference
- Aftern = 130
- Outcome
- Number of RRT catheter-free days
- Follow-up
- Day 28 after initiating RRT
Methodological detailsmulticentre
- Multicentre
Main finding
Catheter-free days · day 28
Adjusted rate ratio
1.11
95% CI 1.03–1.19
P = 0.006
By group
After vs Before
adjusted rate ratio 1.11 (95% CI 1.03–1.19); P = 0.006
As reported in the abstract
Safety
Events
| Outcome | Before | After |
|---|---|---|
| Catheter reinsertion to resume RRT | 3 | 5 |
Original publication
Effects of the urinary urea excretion index on the decision to wean ICU patients with acute kidney injury from renal replacement therapy: a before-after multicentre study (D-STOP). Crit Care. Published 1 July 2025. doi:10.
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