Respiratory failure & ventilation
Acute kidney injury in immunocompromised patients with acute respiratory failure: insights from the HIGH clinical trial and relation with mechanical ventilation
Primary result · AKIResult — go to the resultOdds ratio 1.05 95% CI 0.98–1.13Authors' conclusion
Immunocompromised patients with acute respiratory failure face a significant risk of developing AKI, driven by a combination of factors such as their underlying conditions and disease severity. In contrast, the direct impact of invasive mechanical ventilation appears to be limited, suggesting that mechanical ventilation may not be a primary driver of AKI in this vulnerable patient population.
Study context
- Population
- Immunocompromised patients with acute respiratory failure
- Participants
- 734 patients
- Comparison
- Invasive mechanical ventilation vs no invasive mechanical ventilation
- Invasive mechanical ventilationn = 302
- Primary endpoint
- AKI (prevalence and association with invasive mechanical ventilation)
Methodological detailspost-hoc analysis, overlap weighting, competing risk model
- Post-hoc analysis
- Overlap weighting
- Competing risk model
Primary result
AKI
Odds ratio
1.05
95% CI 0.98–1.13
P = 0.185
Invasive mechanical ventilation vs No invasive mechanical ventilation
OR 1.05 (95% CI 0.98–1.13); P = 0.185
As reported in the abstract
- Patients developing acute kidney injury (AKI)
- 542 (74%)
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| AKI, univariate analysisUnivariate | 1.08 (1.02–1.16) | P = 0.014 | |
| 0.512Odds ratio (log scale) |
| Outcome | Invasive mechanical ventilation |
|---|---|
| AKI after initiation of mechanical ventilation (ventilated patients) | 19% |
Timing: day of peak KDIGO stage vs day of mechanical ventilation initiation
Days
- Peak KDIGO stage, median day
- 2 (IQR 1-4 days)
- Initiation of mechanical ventilation, median day
- 3 (IQR 2-4 days)
Original publication
Acute kidney injury in immunocompromised patients with acute respiratory failure: insights from the HIGH clinical trial and relation with mechanical ventilation. Ann Intensive Care. Published 12 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →