Cardiothoracic & vascular anesthesia
Acute Kidney Injury in Cardiac Surgery: A Comprehensive Review of Perioperative Strategies and Emerging Biomarkers
Authors' conclusion
In conclusion, comprehensive prevention of AKI in cardiac surgery demands a multimodal approach, integrating preoperative risk assessment, intraoperative management, and postoperative care.
Study context
- Population
- Patients undergoing cardiac surgery at risk of cardiac surgery-associated acute kidney injury (AKI) (Cardiac surgery-associated AKI (CSA-AKI))
- Outcome
- Perioperative strategies and emerging biomarkers for CSA-AKI
Main finding
As reported in the abstract
- Serum creatinine has limitations as a diagnostic marker of AKI (KDIGO-based definitions)
- Preoperative risk stratification with validated prediction models (Cleveland Clinic score, EuroSCORE II) is essential
- Intraoperative surgical technique selection and hemodynamic optimization are crucial for preventing AKI
- Postoperative fluid balance and nephrotoxin avoidance are vital
- KDIGO care bundles effective in reducing AKI incidence
- NGAL and KIM-1 promising for early detection of renal injury
Original publication
Acute Kidney Injury in Cardiac Surgery: A Comprehensive Review of Perioperative Strategies and Emerging Biomarkers. J Cardiothorac Vasc Anesth. Published 13 November 2025. doi:10.
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