Cardiac arrest & resuscitation
Acute SARS-CoV-2 Infection and Incidence and Outcomes of Out-of-Hospital Cardiac Arrest
Authors' conclusion
In this cohort study of COVID-19 and OHCA, a substantial proportion of the higher OHCA incidence and lower survival during the pandemic was not directly due to SARS-CoV-2 infection but indirect factors that challenged OHCA prevention and treatment.
Study context
- Population
- Adults (≥18 y) with nontraumatic OHCA attended by emergency medical services (EMS), Seattle and King County, Washington, 2018–20215,979 EMS treated
- Participants
- 13,081 adults
- Exposure
- Pandemic (2020-2021) vs prepandemic (2018-2019) periods; acute SARS-CoV-2 infection vs no acute infection
- Outcome
- OHCA incidence and survival to hospital discharge
Methodological detailsmediation analysis, time-series correlation analysis
- Mediation analysis
- Time-series correlation analysis
Further findings
OHCA incidence
Survival to hospital discharge · mediation analysis
- OHCA incidence — Total number of patients with OHCA increased
- 19.0%
- Survival to hospital discharge — Proportion of pandemic survival decline accounted for by SARS-CoV-2 infection
- 18.5%
- Survival to hospital discharge — Proportion of pandemic survival decline mediated by Utstein elements
- 68.2%
- Survival to hospital discharge during pandemic, acute SARS-CoV-2 infection vs no acute infection (subgroup): Acute SARS-CoV-2 infection 6.2%
- Survival to hospital discharge during pandemic, acute SARS-CoV-2 infection vs no acute infection (subgroup): No acute infection 16.0%
- Acute SARS-CoV-2 infection during pandemic: EMS treated 6.2%
- Acute SARS-CoV-2 infection during pandemic: EMS attended, untreated 3.7%
- Acute SARS-CoV-2 infection during pandemic: 7 of 191
Correlation of community SARS-CoV-2 incidence with OHCA incidence
- Overall OHCA incidence, r (P = .01)
- 0.27
- OHCA incidence with acute SARS-CoV-2 infection, r (P < .001)
- 0.43
- Time-series correlation analysis
Original publication
Acute SARS-CoV-2 Infection and Incidence and Outcomes of Out-of-Hospital Cardiac Arrest. JAMA Netw Open. Published 2 October 2023. doi:10.
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