Cardiac arrest & resuscitation
Presentation and Outcomes of Adults With Overdose-Related Out-of-Hospital Cardiac Arrest
Authors' conclusion
In a population-based cohort study, the incidence of OD-OHCA increased significantly from 2015 to 2021, with the greatest increase observed among patients with a combined stimulant-opioid OHCA. Presentation and outcome differed according to the drug-specific profile.
Study context
- Population
- Adults with EMS-treated Out-of-hospital Cardiac Arrest (OHCA), King County Washington, 2015–2021EMS-treated OHCA
- Participants
- 6,790 adults
- Exposure
- OD-OHCA vs non-OD OHCA
- Overdose (OD)n = 702
- non-ODn = 6,088reference
- Outcome
- Survival to hospital discharge
Main finding
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Values |
|---|---|
| Unwitnessed arrest | OD-OHCA 66% · non-OD OHCA 41% |
| Shockable rhythm | OD-OHCA 8% · non-OD OHCA 25% · Stimulant-only 24% · Opioid-only 4% · Opioid-stimulant 5% |
| Witnessed arrest (drug profiles) | Stimulant-only 50% · Other drugs 19% · Opioid-stimulant 23% |
Incidence of OD-OHCA (per 100 000 person-years) · 2015 to 2021
- Incidence 2015
- 5.2 (95% CI, 3.8-6.6)
- Incidence 2021
- 13.0 (95% CI, 10.9-15.1)
- Trend
- P < 0.001
- No significant temporal change in non-OD OHCA incidence
- P = 0.30
- Greatest relative increase in combined opioid-stimulant OHCA
Original publication
Presentation and Outcomes of Adults With Overdose-Related Out-of-Hospital Cardiac Arrest. JAMA Netw Open. Published 1 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →