Adaptations and Heterogeneity of Treatment Effects in Platform Trials—Protocol for Two Methodological Studies
Authors' conclusion
The two proposed methodological studies will provide an overview of important methodological features regarding the assessment of HTE and adaptations used in adaptive platform trials.
Study context
- Population
- Adaptive platform trials conducted from 2005 onwards
Methodological detailssystematic literature search, duplicate independent screening and data extraction
- Systematic literature search
- Duplicate independent screening and data extraction
Main finding
As reported in the abstract
- Study I: methods used to evaluate heterogeneity of treatment effects (HTE); Study II: adaptations and stopping rules (planned)
- Protocol; no results
Original publication
Adaptations and Heterogeneity of Treatment Effects in Platform Trials—Protocol for Two Methodological Studies. Acta Anaesthesiol Scand. Published 7 May 2025. doi:10.
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