Hemodynamics, fluids & transfusion
Adjunctive Midodrine Therapy for Vasopressor-Dependent Shock in the ICU: A Systematic Review and Meta-Analysis
Authors' conclusion
Adjunctive midodrine may decrease ICU LOS, duration of IV vasopressor therapy, and mortality in critically ill patients.
Study context
- Population
- Critically ill ICU patients with vasopressor-dependent shock7 RCTs · 10 observational studies
- Comparison
- Adjunctive oral midodrine vs placebo or usual care
- Outcome
- Efficacy of adjunctive midodrine (ICU LOS, hospital LOS, IV vasopressor duration, ICU and hospital mortality)
Methodological detailstrial sequential analysis, GRADE
- Trial sequential analysis
- GRADE
Pooled result
As reported in the abstract
- Midodrine may decrease ICU length of stay (LOS)
- Low certainty of effect on hospital LOS
- Midodrine may decrease IV vasopressor duration, ICU mortality and hospital mortality
- Pooled observational data very low certainty for all outcomes
- TSA required sample size not met for ICU LOS or IV vasopressor duration
Original publication
Adjunctive Midodrine Therapy for Vasopressor-Dependent Shock in the ICU: A Systematic Review and Meta-Analysis. Crit Care Med. Published 4 December 2024. doi:10.
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