Hemodynamics, fluids & transfusion
Renin Levels and Angiotensin II Responsiveness in Vasopressor-Dependent Hypotension*
Main finding · Baseline renin levels by recent RAS inhibitor exposureResult — go to the resultRelative increase in baseline renin levels 198 % 95% CI 36–552%Authors' conclusion
In patients with vasopressor-dependent vasodilatory hypotension, recent RAS inhibitor exposure was associated with higher baseline renin levels. Such higher renin levels were then associated with decreased ANGII responsiveness. Higher renin levels at 24 hours despite ANGII infusion were associated with fewer days alive and CRRT-free.
Study context
- Population
- Critically ill adults receiving angiotensin II as primary agent for vasopressor-dependent vasodilatory hypotension, academic ICU, Melbourne, AustraliaAcute Renal effects of Angiotensin II Management in Shock study
- Participants
- 40 adults
- Outcome
- Baseline renin levels by recent renin-angiotensin system (RAS) inhibitor exposure
- Follow-up
- Baseline
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Relative increase in baseline renin levels
198 %
95% CI 36–552%
Recent RAS inhibitor exposure vs No recent exposure
relative increase in baseline renin levels 198 % (95% CI 36–552%)
Observational data: associations, not effects.
Original publication
Renin Levels and Angiotensin II Responsiveness in Vasopressor-Dependent Hypotension*. Crit Care Med. Published 21 March 2024. doi:10.
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