Hemodynamics, fluids & transfusion
Lower Versus Higher Exposure to Vasopressor Therapy in Vasodilatory Hypotension: A Systematic Review With Meta-Analysis*
Pooled resultResult — go to the resultRelative risk 0.94 95% CI 0.87–1.02Authors' conclusion
In patients with vasodilatory hypotension who are started on vasopressors, moderate-certainty evidence from three randomized trials showed that lower vasopressor exposure probably lowers mortality.
Study context
- Population
- Adult ICU patients with vasodilatory hypotension3 RCTs
- Comparison
- Lower vs higher exposure to vasopressor therapy
- Outcome
- All-cause mortality
- Follow-up
- 90 days
Methodological detailsrandom-effects meta-analysis, GRADE certainty assessment, seven prespecified subgroups
- Random-effects meta-analysis
- GRADE certainty assessment
- Seven prespecified subgroups
Pooled result
As reported in the abstract
Relative risk
0.94
95% CI 0.87–1.02
Lower exposure vs Higher exposure
RR 0.94 (95% CI 0.87–1.02)
Further pooled results
90-day mortality, prespecified subgroups (subgroup)
- No credible subgroup effect
Safety
| Outcome | OR (95% CI) | |
|---|---|---|
| Supraventricular arrhythmiaLow certainty | 0.55 (0.36–0.86) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Lower Versus Higher Exposure to Vasopressor Therapy in Vasodilatory Hypotension: A Systematic Review With Meta-Analysis*. Crit Care Med. Published 18 November 2022. doi:10.
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