Cardiothoracic & vascular anesthesia
A Pilot Study of Renin-Guided Angiotensin-II Infusion to Reduce Kidney Stress After Cardiac Surgery
Primary result · Δ-[TIMP-2]*[IGFBP7]Result — go to the resultHodges-Lehmann estimation of the location shift 0.12 [ng/mL] 2 /1000 95% CI −0.1 to 0.36Authors' conclusion
The infusion of AT-II for 12 hours appears feasible and did not lead to an increase in kidney stress in a high-risk cohort of cardiac surgery patients.
Study context
- Population
- Vasoplegic cardiac surgery patients (cardiac index > 2.1l/min, postoperative hypotension requiring vasopressors) with Δ-renin ≥3.7 µU/mL1 excluded
- Participants
- 64 patients
- Comparison
- Angiotensin-II vs placebo targeting MAP ≥65 mm Hg for 12 hours
- Angiotensin-II (AT-II)n = 31
- Placebon = 32reference
- Primary endpoint
- Kidney stress: difference between baseline and 12 hours [TIMP-2]*[IGFBP7] levels
- Follow-up
- 12 hours
Methodological detailspilot, placebo-controlled
- Pilot
- Placebo-controlled
Primary result
Δ-[TIMP-2]*[IGFBP7]
Hodges-Lehmann estimation of the location shift
0.12 [ng/mL] 2 /1000
95% CI −0.1 to 0.36
P = 0.19
Change by group
AT-II
0.06
IQR −0.24–0.28 · [ng/mL] 2 /1000
Placebo
−0.08
IQR −0.35–0.14 · [ng/mL] 2 /1000
As reported in the abstract
Secondary outcomes
Fluid received during treatment
P = 0.03
Norepinephrine equivalent dose
P < 0.001
Safety
Serious adverse events
Original publication
A Pilot Study of Renin-Guided Angiotensin-II Infusion to Reduce Kidney Stress After Cardiac Surgery. Anesth Analg. Published 30 January 2024. doi:10.
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