ICU sedation, delirium & recovery
Adjuvant nefopam versus standard of care in mechanically ventilated surgical critically ill patients: A randomized, double-blind controlled study
Authors' conclusion
Nefopam was found to be an effective non-opioid option for analgesia in mechanically ventilated surgical and trauma critically ill patients
Study context
- Population
- Mechanically ventilated ICU patients who are candidates for analgesia and sedation protocolsincluded in final analysis
- Participants
- 60 participants
- Comparison
- Adjunct nefopam infusion vs standard-of-care analgesia and sedation
- Interventionn = 30
- Controln = 30reference
- Primary endpoint
- Cumulative dose of fentanyl
- Follow-up
- First 24 h after inclusion
Methodological detailsprospective, active control, double-blind
- Prospective
- Active control
- Double-blind
Primary result
As reported in the abstract
Cumulative fentanyl consumption · 24 h
P = 0.001
Secondary outcomes
ICU mortality
P = 0.136
Pain and sedation scores
- Comparable between the two groups
Original publication
Adjuvant nefopam versus standard of care in mechanically ventilated surgical critically ill patients: A randomized, double-blind controlled study. Anaesth Crit Care Pain Med. Published 16 April 2025. doi:10.
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