Age and associated outcomes among patients receiving venoarterial extracorporeal membrane oxygenation–analysis of the Extracorporeal Life Support Organization registry
Authors' conclusion
Among patients receiving V-A ECMO for cardiogenic shock, increasing age is strongly associated with increasing odds of death and complications, and this association emerges as early as 40 years of age.
Study context
- Population
- Adults receiving V-A ECMO, Extracorporeal Life Support Organization registry (440 centers), 2017 to 2019
- Participants
- 15,172 adults · 440 centers
- Exposure
- Increasing age brackets vs age 18-29
- Outcome
- Hospital mortality
Methodological detailsinternational multicentre registry, Bayesian analysis
- International multicentre registry
- Bayesian analysis
Main finding
As reported in the abstract
Each group vs 18-29Odds ratio (95% CrI)
30-39CrI; not associated
0.94(0.79–1.10)
40-49CrI
1.26(1.08–1.47)
50-59CrI
1.78(1.55–2.06)
60-69CrI
2.24(1.94–2.59)
70-79CrI
2.90(2.49–3.39)
≥ 80CrI
4.02(3.13–5.20)
- Overall hospital mortality
- 8172 (53.9%)
Observational data: associations, not effects.
Secondary outcomes
Hospital mortality, informative prior (sensitivity analysis)
- Similar results
Safety
Composite of post-ECMO complications
- Similar association between increasing age and complications
Original publication
Age and associated outcomes among patients receiving venoarterial extracorporeal membrane oxygenation–analysis of the Extracorporeal Life Support Organization registry. Intensive Care Med. Published 4 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →