Obesity Is Associated With Increased Mortality in Patients Undergoing Venoarterial Extracorporeal Membrane Oxygenation
Authors' conclusion
In patients undergoing venoarterial ECMO, increasing BMI was associated with increasing all-cause mortality and mechanical and renal complications.
Study context
- Population
- Patients undergoing venoarterial extracorporeal membrane oxygenation (ECMO) at Extracorporeal Life Support Organization (ELSO) registry contributing centers, 2015–2021
- Participants
- 22,825 venoarterial ECMO runs
- Exposure
- Increasing body mass index (BMI) categories; BMI 35 and 45 vs BMI 25
- Outcome
- All-cause mortality by BMI
Methodological detailsmulticentre registry, logistic regression with fractional polynomials
- Multicentre registry
- Logistic regression with fractional polynomials
Main finding
As reported in the abstract
Each group vs BMI 25Odds ratio (CI)
BMI 35
1.15(1.09–1.18)
BMI 45
1.46(1.25–1.57)
- BMI significantly associated with mortality
- P < 0.001
Observational data: associations, not effects.
Further findings
BMI by survival status
Safety
- BMI significantly associated with increased mechanical and renal complications, but decreased pulmonary complications
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Obesity Is Associated With Increased Mortality in Patients Undergoing Venoarterial Extracorporeal Membrane Oxygenation. Crit Care Med. Published 17 December 2024. doi:10.
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