Impact of Obesity on Neurologic Outcomes in Patients Undergoing Venoarterial Extracorporeal Membrane Oxygenation
Authors' conclusion
Obesity increased the hazard of poor neurologic outcomes, ABI, and mortality in this cohort of patients undergoing VA-ECMO
Study context
- Population
- Adults undergoing venoarterial extracorporeal membrane oxygenation (VA-ECMO)
- Participants
- 214 adults
- Exposure
- Obese vs nonobese
- Obesen = 104
- Nonobesen = 110reference
- Outcome
- Neurologic outcome: good (mRS 0-3) vs poor (mRS 4-6)
- Follow-up
- At discharge
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Poor neurologic outcome at discharge (mRS 4-6) · discharge
P < 0.001
- Obesity associated with increased hazard of poor neurologic outcomes (multivariable Cox model, aHR)
- 1.63 (95% CI 1.15-2.31; p = 0.006)
- Acute brain injury (ABI) associated with increased hazard of poor neurologic outcomes (multivariable Cox model, aHR)
- 1.41 (95% CI 1.01-1.96; p = 0.04)
Observational data: associations, not effects.
Secondary outcomes
Acute brain injury (ABI)
P = 0.04
ABI as risk factor for poor neurologic outcome
| aHR (95% CI) | P value | ||
|---|---|---|---|
| ABIMultivariable Cox regression | 1.41 (1.01–1.96) | P = 0.04 | |
| 0.512Adjusted hazard ratio (log scale) |
| Outcome | P value |
|---|---|
| 90-day survival · log-rank test | P < 0.0001 |
90-day survival
- Lower 90-day survival probability in obese patients (Kaplan-Meier)
Original publication
Impact of Obesity on Neurologic Outcomes in Patients Undergoing Venoarterial Extracorporeal Membrane Oxygenation. J Cardiothorac Vasc Anesth. Published 22 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →