Age-dependent differences in the association between blood interleukin-6 levels and mortality in patients with sepsis: a retrospective observational study
Authors' conclusion
Blood IL-6 levels were significantly associated with mortality in non-elderly patients with sepsis, but not in elderly patients. IL-6 levels were associated with MOD in both groups.
Study context
- Population
- Patients aged ≥ 16 years with sepsis admitted to the ICU at Chiba University Hospital
- Participants
- 272 vs 247
- Exposure
- Non-elderly vs Elderly
- Non-elderlyn = 272
- Elderlyn = 247
- Outcome
- 28-day in-hospital mortality
- Follow-up
- 28 days
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Association between log-transformed IL-6 levels and 28-day in-hospital mortality (Cox regression)
Non-elderlyHazard ratio (95% CI)P value
Univariate
1.71(1.25–2.37)
P < 0.001Adjusted for sex, BMI, steroid use prior to sepsis onset, number of chronic organ dysfunctions
1.66(1.20–2.32)
P = 0.002Observational data: associations, not effects.
Secondary outcomes
Multiple organ dysfunction (MOD) on days 3 and 7 (multivariable logistic regression)
- Significant associations between MOD and IL-6 levels in both groups
Baseline severity (SOFA, APACHE II components, MOD) and outcome measures between groups
- No significant differences between the groups
Original publication
Age-dependent differences in the association between blood interleukin-6 levels and mortality in patients with sepsis: a retrospective observational study. J Intensive Care. Published 13 January 2025. doi:10.
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