Perioperative medicine & outcomes
Age-related changes in intraoperative mean values of nociceptive response in patients undergoing non-cardiac surgery under general anesthesia: A retrospective cohort study
Authors' conclusion
In conclusion, there is likely an association between age and intraoperative mean NR index in patients under general anesthesia.
Study context
- Population
- Consecutive patients of all ages undergoing non-cardiac surgery under GA, January 2019 to July 2023
- Participants
- 22,061 patients
- Exposure
- Association between age and intraoperative mean NR index
- Outcome
- Intraoperative nociception: averaged nociceptive response (mean NR) index during surgery
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Association of age with mean NR index (multivariable regression)
- Significant association between age and mean NR index in all three surgical risk groups
Observational data: associations, not effects.
Further findings
Other preoperative variables and mean NR index
- C-reactive protein (CRP), body mass index (BMI), emergent surgery, AF, renal failure and long-term steroid use significantly associated with mean NR index in all three groups
Mean NR index by age (sensitivity analysis)
- Higher in younger children than in older children and younger adults; gradually increased again in older adults to the level of younger children
Original publication
Age-related changes in intraoperative mean values of nociceptive response in patients undergoing non-cardiac surgery under general anesthesia: A retrospective cohort study. J Clin Monit Comput. Published 27 January 2024. doi:10.
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