Perioperative medicine & outcomes
Associations between intraoperative nociceptive response index and early postoperative acute kidney injury in patients undergoing non-cardiac surgery under general anesthesia: a single-center retrospective cohort study
Authors' conclusion
In addition to intraoperative hypotension, a higher level of intraoperative NR index is likely associated with higher incidence of early postoperative AKI in adult patients undergoing non-cardiac surgery under general anesthesia.
Study context
- Population
- Consecutive adults undergoing non-cardiac surgery under GA, February 2022 to August 2023
- Participants
- 5,765 adults
- Exposure
- Highest intraoperative nociceptive response (NR) index ≥ 0.920 and other factors, association with early postoperative acute kidney injury (AKI)
- Outcome
- Early postoperative AKI
Methodological detailssingle-centre, multivariate regression analysis
- Single-centre
- Multivariate regression analysis
Main finding
As reported in the abstract
Factors associated with early postoperative AKI (multivariate regression)
- Highest NR during surgery ≥ 0.920 significantly associated with early postoperative AKI
- Lowest mean blood pressure (MBP) during surgery < 54 mmHg significantly associated with early postoperative AKI
- Age ≥ 48 years significantly associated with early postoperative AKI
- Male sex significantly associated with early postoperative AKI
- ASA-PS ≥ III significantly associated with early postoperative AKI
- Emergency surgery significantly associated with early postoperative AKI
- Duration of surgery ≥ 226 min significantly associated with early postoperative AKI
Observational data: associations, not effects.
Original publication
Associations between intraoperative nociceptive response index and early postoperative acute kidney injury in patients undergoing non-cardiac surgery under general anesthesia: a single-center retrospective cohort study. J Clin Monit Comput. Published 7 June 2024. doi:10.
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