Hemodynamics, fluids & transfusion
Agreement Between Methods Assessing Changes in Plasma Volume During Fluid Therapy—A Post Hoc Analysis of a Randomized Trial
Authors' conclusion
The anthropometric formula yields low precision in predicting plasma volumes in postsurgical patients. Changes in hematocrit during fluid therapy cannot replace the reference method to assess changes in plasma volume in the individual patient because of the imprecision.
Study context
- Population
- Postoperative patients receiving 10 mL/kg of albumin
- Participants
- 64 patients
- Comparison
- Anthropometric method and calibrated (haematocrit-based) method vs reference method (radiolabeled albumin) for plasma volume
- Primary endpoint
- Agreement in plasma volume between methods (Bland-Altman mean difference and LOA)
- Follow-up
- Baseline, 30 and 180 min
Methodological detailsmethod agreement study, Bland-Altman analysis
- Method agreement study
- Bland-Altman analysis
Primary result
As reported in the abstract
Plasma volume agreement vs reference method
Each group vs reference methodMean difference, mL/kg (95% CI)
Anthropometric methodat baseline; LOA −18.0 and 17.0 mL/kg
−0.1(−2.1 to 1.8)
Anthropometric methodafter fluid therapy; LOAs −18.0 and 17.0 mL/kg
−0.1(−1.8 to 1.5)
Calibrated methodLOAs −9.4 and 9.2 mL/kg
−0.1(−0.9 to 0.7)
Original publication
Agreement Between Methods Assessing Changes in Plasma Volume During Fluid Therapy—A Post Hoc Analysis of a Randomized Trial. Acta Anaesthesiol Scand. Published 4 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →