Airway nerve blocks for awake tracheal intubation: A meta-analysis of randomized control trials and trial sequential analysis
Pooled result · Intubation timeResult — go to the resultSMD −2.57 95% CI −3.59- −1.56Authors' conclusion
Based on current published evidence, airway nerve blocks provide better airway anesthesia quality for ATI with a shorter intubation time, better intubation conditions including higher no reaction to placement of the flexible scope and tracheal tube, lower cough or gag reflex during intubation, higher excellent patient satisfaction, and lower overall complications.
Study context
- Population
- Adults undergoing awake tracheal intubation in randomized controlled trials (RCTs)14 articles
- Participants
- 658 adults
- Comparison
- Airway nerve blocks vs Without nerve blocks
- Outcome
- Intubation time
Methodological detailstrial sequential analysis, Overall quality of evidence moderate
- Trial sequential analysis
- Overall quality of evidence moderate
Pooled result
As reported in the abstract
SMD
−2.57
95% CI −3.59- −1.56
P < 0.00001
Airway nerve blocks vs Without nerve blocks
SMD −2.57 (95% CI −3.59- −1.56); P < 0.00001
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| No reaction to placement of flexible scope and tracheal tube | 9.87 (4.10–23.75) | P < 0.00001 | |
| Cough or gag reflex during intubation | 0.35 (0.27–0.46) | P < 0.00001 | |
| Excellent patient satisfaction | 1.88 (1.05–3.34) | P = 0.03 | |
| 0.050.21520Relative risk (log scale) |
Safety
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Overall complications during ATI | 0.29 (0.19–0.45) | P < 0.00001 | |
| 0.20.5125Relative risk (log scale) |
Original publication
Airway nerve blocks for awake tracheal intubation: A meta-analysis of randomized control trials and trial sequential analysis. J Clin Anesth. Published 11 April 2023. doi:10.
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