Alcohol related hepatitis in intensive care units: clinical and biological spectrum and mortality risk factors: a multicenter retrospective study
Authors' conclusion
Alcohol related hepatitis is a severe condition leading to high mortality in ICU patients. Severity of organ failure at admission are mortality risk factors. Outcome was significantly better in responders to corticosteroids therapy according to Lille score.
Study context
- Population
- Patients with alcohol related hepatitis hospitalised in 9 French intensive care units (ICUs) (2006–2017)
- Participants
- 187 patients
- Outcome
- ICU mortality and its risk factors
Methodological detailsmulticentre, propensity score weighting
- Multicentre
- Propensity score weighting
Main finding
As reported in the abstract
Mortality
- ICU mortality
- 37%
- In-hospital mortality
- 53%
- ICU mortality: SOFA score (without total bilirubin), SHR per one-point increase
- 1.08 [1.02-1.14]
- ICU mortality: arterial lactate, SHR per 1 mmol/L
- 1.08 [1.03-1.13]
- ICU mortality: MELD score, SHR per 1 point
- 1.09 [1.04-1.14]
- Employment, associated with increased survival, HR
- 0.49 [0.28-0.86]
Observational data: associations, not effects.
Further findings
Prognosis in responders by Lille score at day 7
| OR (CI) | P value | ||
|---|---|---|---|
| RespondersBetter prognosis in responders | 6.67 (2.44–20.15) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
Corticosteroids and ICU mortality
- Corticosteroids did not affect ICU mortality overall but had a beneficial effect in patients with histological proof
- Propensity score weighting
Admission severity and ICU support
- Median SOFA score at admission
- 10 [7-13]
- Median MELD score at admission
- 31 [26-40]
- Invasive mechanical ventilation
- 63%
- Vasopressors
- 62%
- Renal replacement therapy
- 36%
- Corticosteroids
- 66%
- Liver transplantation
- 16 (8.5%)
Original publication
Alcohol related hepatitis in intensive care units: clinical and biological spectrum and mortality risk factors: a multicenter retrospective study. Ann Intensive Care. Published 15 April 2025. doi:10.
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