Critically ill severe hypothyroidism: a retrospective multicenter cohort study
Authors' conclusion
SH is a rare life-threatening emergency with various clinical presentations. Hemodynamic and respiratory failures are strongly associated with worse outcomes.
Study context
- Population
- ICU patients with severe hypothyroidism (biological hypothyroidism with ≥1 cardinal sign and ≥1 severe hypothyroidism (SH)-related organ failure), 32 French ICUs over 18 years
- Participants
- 82 patients
- Outcome
- In-ICU and 6-month survival
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Mortality
In-ICU mortality
26%
6-month mortality
39%
Observational data: associations, not effects.
Further findings
Factors independently associated with in-ICU mortality (multivariable analyses)
| OR (CI) | ||
|---|---|---|
| Age > 70 yearsMultivariable analyses | 6.01 (1.75–24.1) | |
| Sequential Organ-Failure Assessment score cardiovascular component ≥ 2Multivariable analyses | 11.1 (2.47–84.2) | |
| Sequential Organ-Failure Assessment score ventilation component ≥ 2Multivariable analyses | 4.52 (1.27–18.6) | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Critically ill severe hypothyroidism: a retrospective multicenter cohort study. Ann Intensive Care. Published 9 March 2023. doi:10.
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