Clinical description and outcome of overall varicella-zoster virus-related organ dysfunctions admitted in intensive care units: the VAZOREA cohort study
Authors' conclusion
Overall, severe VZV manifestations are associated with high mortality in the ICU, which appears to be driven by immunosuppression status rather than any specific organ involvement.
Study context
- Population
- Adults with life-threatening VZV-related events requiring intensive care unit (ICU) admission or occurring in ICU, 26 French ICUs, 2010–2019
- Participants
- 119 adults · 26 French ICUs
- Outcome
- Clinical features and outcome of life-threatening VZV manifestations requiring ICU admission
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Clinical features and outcome
- Median SOFA score
- 6
- Admitted in ICU for VZV disease
- 108 (90.8%)
- VZV disease occurring in ICU
- 11 (9.2%)
- Immunocompromised
- 61 (51.3%)
- Encephalitis
- 55.5%
- Pneumonia
- 44.5%
- Hepatitis
- 9.2%
- Norepinephrine
- 54 (45.4%)
- Invasive mechanical ventilation
- 72 (60.5%)
- RRT
- 31 (26.3%)
- In-hospital mortality
- 36.1%
Observational data: associations, not effects.
Further findings
Phenotypic clusters (hierarchical clustering on principal components)
- In-hospital mortality across phenotypes ranged from zero to 75%
- P < 0.001
- Five clusters: VZV-related pneumonia, mild encephalitis, severe encephalitis in solid organ transplant recipients, encephalitis in other immunocompromised hosts, VZV disease occurring in ICU
Original publication
Clinical description and outcome of overall varicella-zoster virus-related organ dysfunctions admitted in intensive care units: the VAZOREA cohort study. Ann Intensive Care. Published 29 March 2024. doi:10.
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