Pediatric anesthesia & critical care
Alpha‐1‐acid glycoprotein and its potential impact on local anesthetic dose in neonates
Authors' conclusion
Alpha-1-acid-glycoprotein concentrations increase in neonates as a response to surgery regardless of gestational age, sex, or mode of delivery.
Study context
- Population
- Neonates (median 3 days of age) undergoing major surgery
- Participants
- 25 neonates
- Exposure
- 48 h postoperatively vs Preoperatively
- Outcome
- Alpha-1-acid glycoprotein plasma concentrations pre- and postoperatively
Main finding
As reported in the abstract
Alpha-1-acid glycoprotein plasma concentration
P < 0.001
Observational data: associations, not effects.
Further findings
Influence of sex, postnatal age, gestational age, delivery mode
- No influence detected on alpha-1-acid glycoprotein concentrations
Original publication
Alpha‐1‐acid glycoprotein and its potential impact on local anesthetic dose in neonates. Paediatr Anaesth. Published 17 April 2023. doi:10.
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