Alterations in the renin-angiotensin system during septic shock
Authors' conclusion
Septic shock was associated with increased Ang I/Ang II and Ang-(1-7)/Ang II ratios, along with reduced cACE activity, increased cACE2 activity, and elevated cDPP3 concentrations compared to healthy controls.
Study context
- Population
- Patients with septic shock (Sepsis-3), excluding prior Renin-Angiotensin Aldosterone System (RAAS)-modifying medication, prior liver failure (Child-Pugh score > 9) or CKD (eGFR < 30 ml/min/1.73 m²)
- Participants
- 20 vs 30
- Exposure
- Septic shock patients vs healthy controls
- Septic shockn = 20
- Controlsn = 30reference
- Outcome
- Classical and alternative RAAS alterations (RAAS peptide equilibrium concentrations, cACE and cACE2 activities, cDPP3 concentrations)
- Follow-up
- 6 h after diagnosis
Methodological detailsmonocentric, Values measured at diagnosis, 6 h after diagnosis and on days 1 and 3
- Monocentric
- Values measured at diagnosis, 6 h after diagnosis and on days 1 and 3
Main finding
As reported in the abstract
RAAS markers vs controls
- Ang I/Ang II ratio: 1.16 [0.74-3.31] vs 0.34 [0.25-0.43]
- p < 0.05
- Ang-(1-7)/Ang II ratio: 0.15 [0.08-1.30] vs 0.03 [0.02-0.04]
- p < 0.05
- Reduced circulating angiotensin-converting enzyme (cACE) activity: 3.38 [2.29-6.8] vs 7.89 [6.39-9.05] nmol Ang II/L/h
- p < 0.05
- Increased cACE2 activity: 814 [669-1987] vs 214 [132-293] pmol Ang-(1-7)/L/h
- p < 0.05
- Increased cDPP3 concentrations: 54.6 [35-142.2] ng/mL vs 13.7 [11.9-15.4] ng/mL
- p < 0.05
Observational data: associations, not effects.
Original publication
Alterations in the renin-angiotensin system during septic shock. Ann Intensive Care. Published 24 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →