Brain and Muscle ARNT-Like 1 Ameliorates Sepsis-Induced Acute Lung Injury by Orchestrating Endoplasmic Reticulum-Phagy and Mitochondrial Metabolism
Authors' conclusion
BMAL1 is a master regulator of cellular homeostasis in SI-ALI. It protects against lung injury by orchestrating a coordinated response between ER-phagy and mitochondrial metabolism.
Study context
- Population
- Patients with sepsis-induced acute lung injury (SI-ALI) in the ICU of Renmin Hospital of Wuhan University; adult male C57BL/6 mice and MH-S alveolar macrophages
- Participants
- 30 vs 12
- Comparison
- SI-ALI vs Healthy controls
- SI-ALIn = 30
- Healthy controlsn = 12reference
Methodological detailsrandomized, single-centre
- Randomized
- Single-centre
Primary result
As reported in the abstract
BMAL1 expression and prognostic value
BMAL1 significantly lower in nonsurvivors; predictor of 28-day mortality (AUC)
0.8177
Original publication
Brain and Muscle ARNT-Like 1 Ameliorates Sepsis-Induced Acute Lung Injury by Orchestrating Endoplasmic Reticulum-Phagy and Mitochondrial Metabolism. Crit Care Med. Published 1 June 2026. doi:10.
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