Reduced plasma levels of Copine 5 correlate with sepsis-induced vascular leakage and mortality in human patients and a murine sepsis model
Authors' conclusion
These observations from human sepsis patients and a murine sepsis model suggest that reduced plasma levels of CPNE5 may contribute to sepsis-induced vascular leakage and mortality.
Study context
- Population
- Human sepsis patients and healthy donors; septic mice induced by intraperitoneal cecal slurry injection; cultured endothelial cells
- Participants
- 77 vs 44
- Comparison
- Sepsis patients vs healthy donors; CPNE5-KO vs WT mice
- Sepsisn = 77
- Healthy donorsn = 44reference
- Outcome
- Plasma levels of CPNE5, Ang-II, sICAM-1 and SDC-1 at admission, sepsis patients vs healthy donors
- Follow-up
- At admission
Methodological detailshuman case-control plasma measurements, in vitro endothelial cell experiments, murine sepsis model, CPNE5-knockout mice
- Human case-control plasma measurements
- In vitro endothelial cell experiments
- Murine sepsis model
- CPNE5-knockout mice
Main finding
As reported in the abstract
- Plasma CPNE5 significantly reduced in sepsis patients vs healthy donors
- p < 0.01
- Plasma Ang-II, sICAM-1 and SDC-1 markedly elevated in sepsis patients vs healthy donors
- p < 0.01
Original publication
Reduced plasma levels of Copine 5 correlate with sepsis-induced vascular leakage and mortality in human patients and a murine sepsis model. Crit Care. Published 19 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →