Neuroanesthesia & neurocritical care
Altered lower brainstem neurophysiological response is associated with mortality in deeply sedated critically ill patients
Main finding · Day-28 mortalityResult — go to the resultAdjusted hazard ratio 3.0 95% CI 1.7–5.2Authors' conclusion
Impaired neurological and neurophysiological lower brainstem responses are associated with mortality in deeply sedated patients.
Study context
- Population
- Mechanically ventilated adults, comatose or deeply sedated, brain injured or not, still unconscious at day 3Evoked potential (EPs) in 264
- Participants
- 322 participants
- Exposure
- P14-PL > 16 ms vs P14-PL ≤ 16 ms
- P14-PL > 16 msn = 76
- Outcome
- Mortality
- Follow-up
- Day 28
Methodological details2015–2019
- 2015–2019
Main finding
Day-28 mortality
Adjusted hazard ratio
3.0
95% CI 1.7–5.2
P14-PL > 16 ms vs P14-PL ≤ 16 ms
aHR 3.0 (95% CI 1.7–5.2)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Delayed awakening
| aOR (95% CI) | ||
|---|---|---|
| Absent oculocephalogyric reflexOnly reflex associated with delayed awakening | 2.1 (1.1–3.7) | |
| 0.20.5125Adjusted odds ratio (log scale) |
Death by brainstem reflexes
- Absent cough and pupillary light reflexes associated with death
Original publication
Altered lower brainstem neurophysiological response is associated with mortality in deeply sedated critically ill patients. Intensive Care Med. Published 13 June 2025. doi:10.
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