Respiratory failure & ventilation
Alveolar Biomarker Profiles in Subphenotypes of the Acute Respiratory Distress Syndrome
Authors' conclusion
Hyperinflammatory and hypoinflammatory ARDS subphenotypes did not display significant differences in alveolar biologic profiles.
Study context
- Population
- Adults on invasive mechanical ventilation within 48 hours of acute respiratory distress syndrome (ARDS) onset, 5 North American ICUs
- Participants
- 88 adults
- Comparison
- Hyperinflammatory vs hypoinflammatory ARDS (plasma-derived subphenotypes); BALF-derived class 2 vs class 1
- Hypoinflammatoryn = 57reference
- Hyperinflammatoryn = 31
- Class 1n = 25reference
- Class 2n = 63
Methodological detailsmulticentre, latent class analysis
- Multicentre
- Latent class analysis
Primary result
As reported in the abstract
BALF biomarkers, hyperinflammatory vs hypoinflammatory ARDS
- Interleukin-6 and granulocyte colony stimulating factor higher in Hyperinflammatory vs Hypoinflammatory; differences not robust to multiple hypothesis testing
Further findings
BALF biomarkers, BALF-derived Class 2 vs Class 1
- Class 2 significantly higher interleukin-6, von Willebrand factor, soluble programmed cell death receptor-1, % neutrophils and other inflammatory biomarkers vs Class 1
- Minimal overlap of BALF-derived classes with plasma-derived classes; majority of both plasma-derived classes in Class 2
Clinical severity of pulmonary disease
- Class 2 lower PaO2/FiO2 and distinct ventilatory parameters; plasma-derived classes related only to nonpulmonary organ dysfunction
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Alveolar Biomarker Profiles in Subphenotypes of the Acute Respiratory Distress Syndrome. Crit Care Med. Published 8 November 2022. doi:10.
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