Respiratory failure & ventilation
Subphenotype-specific serum proteomic signatures in patients with acute respiratory distress syndrome (ARDS)
Authors' conclusion
Serum proteomic profiling identified distinct protein patterns associated with established ARDS inflammatory subphenotypes, providing insights into the biological heterogeneity of ARDS.
Study context
- Population
- Patients with ARDS classified into hyperinflammatory or hypoinflammatory subphenotypespatients with ARDS · hyperinflammatory subphenotype 13 · hypoinflammatory subphenotype 18
- Participants
- 31 patients
- Exposure
- Serum proteomic profiling to identify differentially abundant proteins between subphenotypes
- Hyperinflammatory subphenotypen = 13
- Hypoinflammatory subphenotypen = 18
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Main finding
As reported in the abstract
P = 0.04
Observational data: associations, not effects.
Further findings
In-hospital mortality · higher in the hyperinflammatory subphenotype
P = 0.01
Differentially abundant serum proteins between subphenotypes
- Serum proteins differentially abundant
- 54
- Categories including endothelial injury, immunoregulation, coagulation/fibrinolysis, complement regulation, tissue remodeling, and metabolism-related proteins
Gene set enrichment analysis
- Pathways differentially enriched between subphenotypes, including cell adhesion, cell-cell signaling, and cytokine responses
- all FDR < 0.10
Cellular expression in external single-cell RNA-seq reference datasets
- Expressed predominantly in CD14 and CD16 monocytes in PBMCs
- Distinct expression patterns across immature and CD163+IL1R2^hi^ circulating neutrophil states
- Expressed mainly in macrophage and monocyte populations, with additional epithelial expression, in tracheal aspirates
Original publication
Subphenotype-specific serum proteomic signatures in patients with ARDS. J Intensive Care. Published 1 October 2026. doi:10.
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