Pediatric anesthesia & critical care
Alveolar target ventilation and dead space in children under anaesthesia: The proventiped cohort study
Authors' conclusion
Total dead space volume (including apparatus dead space) represents a major component of tidal volume in children less than 30 kg, when using large heat and moisture exchanger filters. The total minute ventilation necessary to achieve normocapnia decreased with increasing weight, while the alveolar minute ventilation remained constant.
Study context
- Population
- Children 2 months to 12 years, 5 to 40 kg, under GA with mechanical ventilation, tertiary care children's hospital, May–October 20197 excluded for aberrant capnographic curves
- Participants
- 60 children
- Exposure
- Weight groups: 5 to 10 kg vs 10 to 20 kg vs 20 to 40 kg
- Group 1n = 20
- Group 2n = 20
- Group 3n = 20
- Outcome
- Total and alveolar minute ventilation (ml kg −1 min −1) to sustain normocapnia, by volumetric capnography
- Follow-up
- Over 100 breaths
Methodological detailssingle-centre, Volumetric capnography used to estimate alveolar and dead space volume
- Single-centre
- Volumetric capnography used to estimate alveolar and dead space volume
Main finding
As reported in the abstract
Total normalised minute ventilation to obtain normocapnia
P < 0.001
- Alveolar minute ventilation similar between the three groups (mean ± SD), ml kg −1 min −1
- 68 ± 21
Observational data: associations, not effects.
Further findings
Tidal volume per kg — group 1 vs group 3 · three-group comparison; similar
P = 0.3
| Outcome | R (95% CI) | P value |
|---|---|---|
| Total Vd (ml kg −1) vs weightNegative correlation | −0.62 (−0.41 to −0.76) | P < 0.001 |
Original publication
Alveolar target ventilation and dead space in children under anaesthesia: The proventiped cohort study. Eur J Anaesthesiol. Published 12 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →