Respiratory failure & ventilation
An Electronic Health Record-Based Classifier for Moderate-to-Severe Acute Respiratory Distress Syndrome With Persistent Hypoxemia
Authors' conclusion
An EHR-based classifier using readily available data had acceptable performance for identifying patients with persistent moderate-severe ARDS.
Study context
- Population
- Adults receiving ≥24 hours of invasive mechanical ventilation with PaO2/FiO2 ≤150 mm Hg on FiO2 ≥0.6 in the first 72 hours
- Participants
- 924 vs 90
- Exposure
- Development vs Validation
- Developmentn = 924
- Validationn = 90
- Outcome
- Primary electronic health record (EHR)-based classifier
Methodological detailstwo health systems, six ICUs, temporally and geographically distinct development and validation cohorts
- Two health systems
- Six ICUs
- Temporally and geographically distinct development and validation cohorts
Main finding
As reported in the abstract
| Group | Value | PPV |
|---|---|---|
| Development | 382 events | 71%; 95% CI, 66-75% |
| Validation | 38 events | 66%; 95% CI, 50-81% |
Value
Development382 events
Validation38 events
PPV
Development71%; 95% CI, 66-75%
Validation66%; 95% CI, 50-81%
Observational data: associations, not effects.
Further findings
Clinician-adjudicated ARDS
Classifier using SpO2/FiO2 ≤162 as second hypoxemia marker
PPV
Classifier using SpO2/FiO2 ≤162 as second hypoxemia marker
- More patients classified as acute respiratory distress syndrome (ARDS) in both cohorts but with lower PPVs
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
An Electronic Health Record-Based Classifier for Moderate-to-Severe Acute Respiratory Distress Syndrome With Persistent Hypoxemia. Crit Care Med. Published 30 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →