Respiratory failure & ventilation
Prone Positioning in a North American Cohort of Hypoxemic Patients on Mechanical Ventilation
Authors' conclusion
In a North American cohort of proning-eligible patients, proning increased during the pandemic and then declined.
Study context
- Population
- Mechanically ventilated adults with persistent moderate-to-severe hypoxemia (PaO2/FiO2 ≤ 150 mm Hg, FiO2 ≥ 0.6, PEEP ≥ 5 cm H2O), 37 North American hospitalsproning-eligible
- Participants
- 5,944 participants
- Exposure
- Proning use across pre-pandemic, pandemic and post-pandemic periods
- Outcome
- Proning use
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Adjusted odds ratio (95% CI)
Pandemic vs Pre-pandemic
7.6(5.5–10.4)
Pandemic vs Post-pandemic
2.7(1.8–3.9)
- Overall proning
- 2155 (36.2%)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Proning by SARS-CoV-2 status (subgroup)Pandemic SARS-CoV-2 positive vs Pandemic SARS-CoV-2 negative | 5.1 (4.1–5.6) | |
| Proning by SARS-CoV-2 status (subgroup)Pandemic SARS-CoV-2 negative vs Pre-pandemic | 3.8 (2.7–5.2) | |
| Proning by SARS-CoV-2 status (subgroup)Pandemic SARS-CoV-2 negative vs Post-pandemic · smaller and not significant | 1.3 (0.9–1.8) | |
| 0.20.5125Odds ratio (log scale) |
Median OR
| Outcome | Pre-pandemic | Pandemic | Post-pandemic |
|---|---|---|---|
| Between-hospital variation in proning (median OR)CrI | 2.9 (95% CrI 1.9–5.3) | 1.9 (95% CrI 1.6–2.3) | 2.3 (95% CrI 1.8–3.3) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prone Positioning in a North American Cohort of Hypoxemic Patients on Mechanical Ventilation. Crit Care Med. Published 22 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →