An individualised tapering protocol reduces opioid use 1 year after spine surgery: A randomised controlled trial of patients with preoperative opioid use
Authors' conclusion
These results suggest that an individualised tapering plan at discharge combined with telephone counselling 1 week after discharge can reduce opioid use 1 year after spine surgery.
Study context
- Population
- Patients with preoperative opioid use undergoing elective spine surgery for degenerative disease, Aarhus University Hospital, Denmark94% responded at 1 year
- Participants
- 110 patients
- Comparison
- Intervention vs Control
- Interventionn = 55
- Controln = 55reference
- Primary endpoint
- Successful tapering to zero opioid use
- Follow-up
- 1 year after discharge
Methodological detailsprospective, single-centre, 1-year follow-up
- Prospective
- Single-centre
- 1-year follow-up
Primary result
As reported in the abstract
Tapered to zero opioid use
Intervention
0.81
42 of 55
Control
0.61
31 of 55
P = 0.026
Further findings
Proportion
| Outcome | Intervention | Control | P value |
|---|---|---|---|
| Unable to taper to preoperative dose · 1 year after discharge | 0.02 (95% CI 0.01–0.13) | 0.14 (95% CI 0.07–0.26) | P = 0.025 |
Back/neck and radicular pain intensity · 1 year
- Similar between study groups
Original publication
An individualised tapering protocol reduces opioid use 1 year after spine surgery: A randomised controlled trial of patients with preoperative opioid use. Acta Anaesthesiol Scand. Published 18 May 2023. doi:10.
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