Neuroanesthesia & neurocritical care
Intraoperative Clonidine in Spine Surgery: A Randomised Controlled Trial
Authors' conclusion
A single dose of intraoperative clonidine did not reduce post-operative opioid consumption or pain intensity in patients undergoing spine surgery.
Study context
- Population
- Patients undergoing spine surgery at Aarhus University Hospital, Denmarkavailable for analysis
- Participants
- 120 patients
- Comparison
- Single dose of intraoperative IV clonidine vs placebo
- Clonidinen = 61
- Placebon = 59reference
- Primary endpoint
- Opioid consumption
- Follow-up
- First 3 h after surgery
Methodological detailsdouble-blinded, placebo-controlled
- Double-blinded
- Placebo-controlled
Primary result
As reported in the abstract
Post-operative IV morphine equivalents · within 3 h
P = 0.58
Secondary outcomes
| Outcome | Clonidine | Placebo | P value |
|---|---|---|---|
| Pain intensity at rest · upon arrival at the PACU | 4 (range or IQR (as printed) 0–5.5) | 3 (range or IQR (as printed) 0–5) | P = 0.20 |
Other secondary outcomes
- No differences between clonidine and placebo in any secondary outcome except hypotension
Safety
Events
| Outcome | Clonidine | Placebo |
|---|---|---|
| Hypotension | 24 | 13 |
Hypotension
- More frequent with clonidine
Original publication
Intraoperative Clonidine in Spine Surgery: A Randomised Controlled Trial. Acta Anaesthesiol Scand. Published 7 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →