Respiratory failure & ventilation
An Initial Investigation of Diaphragm Neurostimulation in Patients with Acute Respiratory Distress Syndrome
Authors' conclusion
This proof-of-concept study showed the feasibility of short-term diaphragm neurostimulation in conjunction with mechanical ventilation in ARDS patients. Diaphragm neurostimulation was associated with positive effects on lung mechanics and on hemodynamics.
Study context
- Population
- Patients with moderate acute respiratory distress syndrome (ARDS) after 48 h of invasive MV12 analysed
- Participants
- 13 patients
- Comparison
- Volume-controlled MV + diaphragm neurostimulation vs MV alone
- Outcome
- PaO2/FiO2 ratio
- Follow-up
- End of each session
Methodological detailsproof-of-concept, crossover (alternating sessions), Catheter could not be inserted in 1 of 13 patients
- Proof-of-concept
- Crossover (alternating sessions)
- Catheter could not be inserted in 1 of 13 patients
Main finding
As reported in the abstract
- PaO2/FiO2 ratio did not change during the four sessions
Secondary outcomes
Plateau pressure
Driving pressure
End-inspiratory transpulmonary pressure
Cardiac index
Median
| Outcome | Mechanical ventilation + neurostimulation | Mechanical ventilation |
|---|---|---|
| Dorsal/ventral ventilation surface ratio | 1.20 (IQR 0.76–1.33) | 0.70 (IQR 0.54–0.91) |
Safety
Tolerance
- All sessions conducted without interruption and well tolerated
Original publication
An Initial Investigation of Diaphragm Neurostimulation in Patients with Acute Respiratory Distress Syndrome. Anesthesiology. Published 13 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →