Respiratory failure & ventilation
Continuous On-Demand Diaphragm Neurostimulation to Prevent Diaphragm Inactivity During Mechanical Ventilation: A Phase 1 Clinical Trial (STIMULUS)
Authors' conclusion
Continuous on-demand diaphragm neurostimulation-assisted mechanical ventilation is feasible and can prevent diaphragm inactivity during mechanical ventilation.
Study context
- Population
- Patients receiving invasive mechanical ventilation for acute hypoxemic respiratory failure or after thoracic surgery
- Participants
- 20 patients · 19 underwent study procedures
- Outcome
- Coprimary: safety and feasibility of maintaining diaphragm activity
- Follow-up
- First 24 hours of intervention
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
Feasibility of maintaining diaphragm activity · initial 24 hours
| Group | Value | Neurostimulation successfully initiated |
|---|---|---|
| Diaphragm neurostimulation | 95% | 19 (100%) |
Diaphragm neurostimulation
Value95%
Neurostimulation successfully initiated19 (100%)
Further findings
| Outcome | Values |
|---|---|
| Hours with absent respiratory drive with diaphragm activity maintained · 7-day study period | Diaphragm neurostimulation median 100% (IQR 95–100%) |
Safety
| Outcome | Values |
|---|---|
| Pneumothorax | Diaphragm neurostimulation 1 events |
- Pneumothorax: unrelated to the device; after subclavian catheter placement before surgery
Pneumothorax
- Diaphragm neurostimulation well tolerated
Original publication
Continuous On-Demand Diaphragm Neurostimulation to Prevent Diaphragm Inactivity During Mechanical Ventilation: A Phase 1 Clinical Trial (STIMULUS). Am J Respir Crit Care Med. Published 1 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →