Anaesthetic efficacy and postinduction hypotension with remimazolam compared with propofol: a multicentre randomised controlled trial
Primary resultResult — go to the resultMean difference −6.28 % 97.5% CI −8.89-infiniteAuthors' conclusion
In conclusion, in patients who were ASA physical status 3 or 4, the anaesthetic effect of remimazolam was non-inferior to propofol.
Study context
- Population
- ASA physical status 3 or 4 patients scheduled for elective surgery
- Participants
- 365 participants
- Comparison
- TIVA with remimazolam vs propofol
- Remimazolamn = 270
- Propofoln = 95reference
- Primary endpoint
- Anaesthetic effect: percentage of time with Narcotrend Index values ≤ 60 during surgery (skin incision to last skin suture)
Methodological detailsphase 3, multicentre, non-inferiority
- Phase 3
- Multicentre
- Non-inferiority
Primary result
As reported in the abstract
Mean difference
−6.28 %
97.5% CI −8.89-infinite
P = 0.003
By group
Secondary outcomes
| Outcome | Remimazolam | Propofol | P value |
|---|---|---|---|
| Postinduction hypotension events (number)Mean | 62 (SD 38.1) | 71 (SD 41.1) | P = 0.015 |
| Noradrenaline administration events (bolus and/or infusion)Lower with remimazolam | 14 (SD 13.5) | 20 (SD 14.6) | P < 0.001 |
Original publication
Anaesthetic efficacy and postinduction hypotension with remimazolam compared with propofol: a multicentre randomised controlled trial. Anaesthesia. Published 14 January 2024. doi:10.
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