Effect of the addition of a low-dose of ketamine to propofol anaesthesia on the phase-amplitude coupling features of an electroencephalogram
Authors' conclusion
This study demonstrates the effect of low-dose ketamine on EEG phase-amplitude coupling during total intravenous anaesthesia with propofol.
Study context
- Population
- Patients aged 28–66 yr, ASA physical status 1 or 2, undergoing surgery under propofol total intravenous anaesthesia (TIVA), given low-dose ketamine (0.5 mg kg-1 bolus, then 0.125 mg kg-1 h-1)
- Participants
- 19 patients
- Exposure
- Frontal EEG before vs 10 and 20 min after low-dose ketamine during propofol TIVA
- Outcome
- EEG modulation index and preferred phase (delta-alpha phase-amplitude coupling)
Main finding
As reported in the abstract
Delta-alpha EEG modulation index (×103)
PreKet
0.47
95% CI 0.25–0.69
PostKet1
0.46
95% CI 0.20–0.73
PostKet2
0.35
95% CI 0.15–0.55
P = 0.623
Observational data: associations, not effects.
Further findings
Mean, °
| Outcome | PreKet | PostKet2 | P value |
|---|---|---|---|
| Mean preferred phase (delta phase at maximal alpha amplitude)PostKet2 vs PreKet · significant shift | 88 (95% CI 50°−126°) | 29 (95% CI −10° to 69°) | P = 0.021 |
Original publication
Effect of the addition of a low-dose of ketamine to propofol anaesthesia on the phase-amplitude coupling features of an electroencephalogram. BJA Open. Published 12 September 2025. doi:10.
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