Frontal Electroencephalogram Phase–Amplitude Coupling Reflects Nociception and the Analgesic Effect of Transversus Abdominis Plane Block in Laparoscopic Surgery
Main finding · Delta-alpha PAC change and nerve block effect during incisionResult — go to the resultCoefficient 0.81 95% CI 0.11–1.51Authors' conclusion
Laparoscopic surgical stimulation reduces EEG alpha power and delta-alpha PAC. Delta-alpha PAC demonstrated greater sensitivity than alpha power measures in distinguishing nociceptive input and reflecting the nerve block effects, suggesting its potential as an intraoperative nociception-analgesia marker.
Study context
- Population
- Patients undergoing laparoscopic surgery
- Participants
- 58 patients
- Exposure
- GA combined with TAP block vs conventional GA
- Outcome
- Delta-alpha PAC change and nerve block effect during incision
- Follow-up
- Surgical incision
Main finding
As reported in the abstract
Coefficient
0.81
95% CI 0.11–1.51
P = 0.02
Observational data: associations, not effects.
Further findings
Association of perioperative EEG patterns with postoperative pain scores
- No association observed
Original publication
Frontal Electroencephalogram Phase–Amplitude Coupling Reflects Nociception and the Analgesic Effect of Transversus Abdominis Plane Block in Laparoscopic Surgery. Anesthesiology. Published 20 January 2026. doi:10.
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