Electroencephalogram Correlates of Delayed Emergence After Remimazolam-Induced Anesthesia Compared to Propofol
Authors' conclusion
Dynamic changes in prefrontal EEG during recovery and the correlation analyses show the potential of EEG in reflecting distinct consciousness recovery profiles between 2 drugs-slower recovery under remimazolam anesthesia.
Study context
- Population
- Adults (age >18) undergoing laparoscopic cholecystectomy
- Participants
- 48 adults
- Comparison
- Remimazolam- vs propofol-induced GA
Methodological detailsmechanistic EEG analysis
- Mechanistic EEG analysis
Primary result
As reported in the abstract
Prefrontal EEG during emergence · emergence
- Theta power, eyes-open: remimazolam mean 2.933 (SD 5.762) vs propofol −2.342 (4.869)
- P -value of 0.018
- Alpha power, eyes-closed: 5.821 (7.35) vs −2.399 (4.53)
- P < .001
- Alpha power, eyes-open: 4.84 (6.411) vs −3.613 (4.556)
- P < .001
- Alpha phase lag entropy (PLE), eyes-closed: 0.619 (0.0338) vs 0.684 (0.0392)
- P < .0001
- Alpha PLE, eyes-open: 0.651 (0.0358) vs 0.692 (0.0428)
- P = .015
- Beta PLE, eyes-closed: 0.682 (0.0308) vs 0.712 (0.0236)
- P = .016
- Beta PLE, eyes-open: 0.695 (0.0236) vs 0.725 (0.0195)
- P < .001
Further findings
Mean
| Outcome | Remimazolam | Propofol | Median difference | P value |
|---|---|---|---|---|
| PSI at PACU, eyes-closed | 65.10 (SD 14.67) | 82.40 (SD 6.678) | P < 0.0001 | |
| PSI at PACU, eyes-open | 72.35 (SD 12.55) | 83.53 (SD 6.632) | P = 0.006 | |
| Time to Aldrete score 9IQR 0.0-21.0; slower under remimazolam | 17.5 | P < 0.001 |
Correlation of time to Aldrete 9 with alpha-band connectivity during deep anaesthesia (remimazolam)
- PLE, Pearson's correlation
- −.78
- Phase lag index (PLI), Pearson's correlation
- .69
- PLE P < .0001; PLI P = .028
Original publication
Electroencephalogram Correlates of Delayed Emergence After Remimazolam-Induced Anesthesia Compared to Propofol. Anesth Analg. Published 25 April 2025. doi:10.
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